Gene Silencing : A brief review
Gene Silencing : A brief review Controlling the expression of genes is a phenomenon known as gene silencing. There are two ways to regulate gene expression: translation and transcription. Gene silencing and gene knockdown, in which gene expression is decreased, are quite similar. It must be distinguished from gene knockout, which is the total removal of a gene from the genome. Silencing of Transcriptional Genes Transcriptional gene silencing is the term used to describe the silencing of genes at the transcriptional level. It is a process of alteration in which the machinery of transcription is disabled. The techniques for transcriptional gene silencing are as follows: Mendelian inheritance is the basis for the epigenetic approach known as genomic imprinting. The genes that children acquire from their parents determine how those genes are expressed in them. Histone modification or DNA methylation silences the gene, which is passed down unchanged to the progeny. Paramutatio...